House of Representatives on Saturday night passed a sweeping health care bill by a vote of 220-215.
In the final tally, 219 Democrats voted for the legislation, and 39 voted against it.
Rep. Joe Cao (R-Louisiana) was the only Republican who voted in favor of the bill.
President Obama said members of the House of Representatives face the chance of a lifetime as they consider the legislation.
The President told lawmakers that "opportunities like this come around maybe once in a generation."
"This is your moment, this is our moment, to live up to the trust that the American people have placed in us."
"Even when it's hard, especially when it's hard, this is our moment to deliver."
Handing President Obama a hard-fought victory, lawmakers voted to approve a $1.1 trillion, 10-year plan that Democrats said could be their defining social policy achievement.